HOME arrowResearch arrowResearchers List arrowNAKAMURA, Akihiko

Researchers detail

Assistant Professor


TEL: 0564-59-5233
Mail: aki-naka_at_ims.ac.jp (Please replace the "_at_" with @ )
Affiliation laboratory:
Location: Yamate, No.2 Bldg. 4F east


Life and Coordination-Complex Molecular Science, Biomolecular Functions


2009 Bachelor, University of Tokyo
2011 Master, University of Tokyo
2014 Ph. D, University of Tokyo
2015 Assistant Professor, Okazaki Institute for Integrative Bioscience (-2018.3)
2018 Assistant Professor, Institute for Molecular Science

Specialized field

Biochemistry, Structural biology

Main research themes

Single molecule analysis of cellulase

Selected Publications

  1. Nakamura, A., Tsukada, T., Auer, S., Furuta, T., Wada, M., Koivula, A., et al. (2013).
    The Tryptophan Residue at the Active Site Tunnel Entrance of Trichoderma reesei Cellobiohydrolase Cel7A Is Important for Initiation of Degradation of Crystalline Cellulose.
    J. Biol. Chem., 288(19), 13503–13510. doi:10.1074/jbc.M113.452623
  2. Nakamura, A, Ishida, T, Fushinobu, S, Kusaka, K, Tanaka, I, Inaka, K, Higuchi Y, Masaki M, Ohta K, Kaneko S, Niimura N, Igarashi K, and Samejima M. (2013).
    Phase-diagram-guided method for growth of a large crystal of glycoside hydrolase family 45 inverting cellulase suitable for neutron structural analysis.
    J. Synchrotron Radiat., 20(6), 859–863.
  3. Nakamura A, Watanabe H, Ishida T,Uchihashi T, Wada M, Ando T, Igarashi K and Samejima M (2014).
    Trade-off between processivity and hydrolytic velocity of cellobiohydrolases at the surface of crystalline cellulose.
    J. Am. Chem. Soc., 136(12), 4584–4592. doi:10.1021/ja4119994
  4. Shibafuji Y, Nakamura A, Uchihashi T, Sugimoto N, Fukuda S, Watanabe H, Samejima M, Ando T, Noji H, Koivula A, Igarashi K, Iino R. (2014).
    Single-molecule imaging analysis of elementary reaction steps of Trichoderma reesei cellobiohydrolase I (Cel7A) hydrolyzing crystalline cellulose Iα and IIII.
    J. Biol. Chem., doi: 10.1074/jbc.M113.546085