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Researchers detail

Assistant Professor

YAGI-UTSUMI, Maho

TEL: 0564-59-5226
Mail: mahoyagi_at_ims.ac.jp (Please replace the "_at_" with @ )
Affiliation laboratory:
Location: Yamate, Yamate No.3 Bldg. 3F west

Department

Exploratory Research Center on Life and Living Systems, Department of Creative Research, Biomolecular Organization Research Group
Exploratory Research Center on Life and Living Systems, Section for Exploration of Life in Extreme Environments,Extreme Environmental Biomolecular Research Group (adjunct)

Life and Coordination-Complex Molecular Science, Biomolecular Functions (adjunct)

Biography

2005  B.S. Nagoya City University 
2010  Ph.D.  Nagoya City University
2009  JSPS Research Fellow, Nagoya City University     
2011  Postdoctral Fellow, Okazaki Institute for Integrative Bioscience     
2013  Visiting Researcher, University of Cambridge     
2014  Research Assistant Professor, Okazaki Institute for Integrative Bioscience
2015  Assistant professor, Institute for Molecular Science (-2018.3)
2018  Assistant professor, Exploratory Research Center on Life and Living Systems

Awards

2007 The Highest Award, Physical Pharm Forum, the Division of Physical Sciences, the Pharmaceutical Society of Japan
2007 Incentive Award, the Japanese Biochemical Society, Chubu Branch
2010 Incentive Award, the Japanese Biochemical Society, Chubu Branch
2011 Young Scientist Award, the Protein Science Society of Japan
2018 Incentive Award 2018, the Pharmaceutical Society of Japan.

Specialized field

NMR, Structural Biology, Biophysics, Protein Science

Main research themes

kewords Amyloid, Glycolipid, NMR

Selected Publications

  1. Yagi-Utsumi, M., Sikdar, A., Kozai, T., Inoue, R., Sugiyama, M., Uchihashi, T., Yagi, H., Satoh, T. and Kato, K.
    Conversion of functionally undefined homopentameric protein PbaA into a proteasome activator by mutational modification of its C-terminal segment conformation.
    Protein Eng. Des. Sel. 31, 29-36 (2018).
  2. Yagi-Utsumi, M., Yamaguchi, T., Uekusa, Y. and Kato, K.
    NMR Characterization of the Conformations, Dynamics, and Interactions of Glycosphingolipids. NMR in Glycoscience and Glycotechnology (Kato K. and Peters T ed.), RCS Publishing (Cambridge), pp.161-178 (2017).
  3. Yagi-Utsumi, M., Kato, K., and Nishimura, K.
    Membrane-induced dichotomous conformation of amyloid β with the disordered N-terminal segment followed by the stable C-terminal β structure.
    PLoS One. 11, e0146405 (2016).
  4. Yagi-Utsumi, M., and Dobson, CM.
    Conformational effects of the A21G Flemish mutation on the aggregation of amyloid β peptide. Biol. Pharm. Bull. 38, 1668-1672 (2015).
  5. Yagi-Utsumi, M., Satoh, T., Kato, K.
    Structural basis of redox-dependent substrate binding of protein disulfide isomerase. Sci. Rep. 5, 13909 (2015).