120-year-old reaction turned on its head with environment-friendly, paste-based method

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2021/11/18

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120-year-old reaction turned on its head with environment-friendly, paste-based method

A new method for creating one of chemistry’s most widely used class of compounds could revolutionize industrial processes, making them cheaper, simpler and more environmentally friendly.

(Left) Reaction mixture of magnesium metal and organohalide after one hour of ball milling. Use of this material in subsequent reactions led to only a 6% yield of the desired product. (Right) Same process, but with a small amount of organic solvent also added at the beginning. Use of this paste form of Grignard reagent in subsequent reactions led to yields of up to 94% of the desired product (Photo: Koji Kubota).

For details, please see the following link: https://www.icredd.hokudai.ac.jp/research/6519

Information of the paper

Authors: Rina Takahashi, Anqi Hu, Pan Gao, Yunpeng Gao, Yadong Pang, Tamae Seo, Julong Jiang, Satoshi Maeda, Hikaru Takaya, Koji Kubota, Hajime Ito
Journal Name: Nature Communications
Journal Title: “Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis”
DOI：10.1038/s41467-021-26962-w

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