分子科学研究所

Site Search

About IMS

Research

Graduate University

Life@Okazaki

Access   Researchers List   Publication
Contact
Japanese

Research

Researchers detail

IMS Researchers

HOME - Research - Researchers detail - KOSUGI, Takahiro
Research

KOSUGI, Takahiro

Assistant Professor

TEL: 0564-55-7379、0564-55-7382
E-Mail : takahirokosugi_at_ims.ac.jp (Please replace the "_at_" with @ )
Location: Myodaiji, South Laboratory Bldg. Room310, Laboratory Bldg. Room406

Affiliation laboratory >

Department

Research Center of Integrative Molecular Systems, Division of Trans-Hierarchical Molecular Systems

Biography

2005 B.S. Kyoto University 
2012 Ph.D.  Kyoto University
2008 JSPS Fellow (DC2)   
2012 JSPS Fellow for Research Abroad    
2014 Postdoctral Fellow, University of Washington   
2015 Assistant Professor, Institute for Molecular Science  

Awards

2013 Best Presentation Award at the 41th Symposium of Structure-Activity Relationships        
2014 Best Presentation Award at the Anuual Meeting of the Japan Society for Molecular Science
2021 The Young Scientist Excellence Award of Protein Science Society of Japan

Specialized field

Biophysics, Theoretical Chemistry

Main research themes

Study Protein Functions by Designing Proteins
kewords Protein Design, Theoretical Chemistry, Molecular Simulation, Biochemistry, Directed Evolution

Selected Publications

  1. QM/MM Reweighting Free Energy SCF for Geometry Optimization on Extensive Free Energy Surface of Enzymatic Reaction.
    Takahiro Kosugi and Shigehiko Hayashi. J. Chem. Theory Comput. 2012, 8, 322-334.
  2. Crucial Role of Protein Flexibility in Formation of a Stable Reaction Transition State in an a-amylase Catalysis.
    Takahiro Kosugi and Shigehiko Hayashi. J. Am. Chem. Soc. 2012, 134, 7045-7055.
  3. Design of allosteric sites into rotary motor V1-ATPase by restoring lost function of pseudo-active sites.
    Takahiro Kosugi, Tatsuya Iida, Mikio Tanabe, Ryota Iino and Nobuyasu Koga. Nat. Chem. 2023, 15, 1591-1598.
  4. Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes.
    Yoshiaki Kamada, Chiharu Umeda, Yukio Mukai, Hokuto Ohtsuka, Yoko Otsubo, Akira Yamashita, Takahiro Kosugi. J. Cell Sci. 2024, 137, jcs261625.
Awards & Honors International collaboration

Links

英_TILAコンソーシアム