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Life and Coordination-Complex Molecular Science Kato(K) Group

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Location: Yamate, No.3 Bldg. west
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Biomolecule, Dynamical Ordering, NMR

Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions

Living systems are characterized as dynamic processes of assembly and disassembly of various biomolecules that are self-organized, interacting with the external environment. The omics-based approaches developed in recent decades have provided comprehensive information regarding biomolecules as parts of living organisms. However, fundamental questions still remain unsolved as to how these biomolecules are ordered autonomously to form flexible and robust systems. Biomolecules with complicated, flexible structures are selforganized through weak interactions giving rise to supramolecular complexes that adopt their own dynamic, asymmetric architectures. These processes are coupled with expression of integrated functions in the biomolecular systems.

Toward an integrative understanding of the principles behind the biomolecular ordering processes, we conduct multidisciplinary approaches based on detailed analyses of dynamic structures and interactions of biomolecules at atomic level, in conjunction with the methodologies of molecular and cellular biology along with synthetic and computational technique.


Formation of supramolecular machinery through dynamic assembly and disassembly of biomolecules.

Selected Publications

  1. Yagi,H., Yanaka,S. and Kato,K., “Structure and dynamics of immunoglobulin G glycoproteins,” Glycobiophysics (Y.Yamaguchi and K.Kato ed.), Springer Nature Singapore, pp.219-235 (2018).
  2. Satoh,T. and Kato,K., “Structural aspects of ER glycoprotein quality-control system mediated by glucose tagging,” Glycobiophysics (Y.Yamaguchi and K.Kato ed.), Springer Nature Singapore, pp.149-169 (2018).
  3. Kato, K. and Satoh, T., “Structural insights on the dynamics of proteasome formation,” Biophys. Rev.10, 597-604 (2018).
  4. Kato, K., Yanaka, S. and Yagi, H., “Technical basis for nuclear magnetic resonance approach for glycoproteins,” Experimental Approaches of NMR Spectroscopy (The Nuclear Magnetic Resonance Society of Japan ed.), Springer Nature Singapore, pp.415-438 (2018).
  5. Matsuzaki, K., Kato, K. and Yanagisawa, K., “Ganglioside-mediated assembly of amyloid β-protein: Roles in Alzheimer's disease,” Prog. Mol. Biol. Transl. Sci.156, 413-434 (2018).
  6. Ikeya, T., Ban, D., Lee, D., Ito, Y., Kato, K. and Griesinger, C., “Solution NMR views of dynamical ordering of biomacromolecules,” Biochim. Biophys. Acta –General Subjects1862, 287-306 (2018).