分子科学研究所

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AKIYAMA, Shuji

Professor

TEL: 0564-55-7363
E-Mail : akiyamas_at_ims.ac.jp (Please replace the "_at_" with @ )
Location: Myodaiji, South Laboratory Bldg. Room313

Affiliation laboratory >


Department

Research Center of Integrative Molecular Systems, Division of Trans-Hierarchical Molecular Systems
Department of Life and Coordination-Complex Molecular Science, Biomolecular Sensing (Concurrent Position)

Biography

1997  B. Tech. Kyoto Univ
1999  M. Tech. Kyoto Univ
2002  Ph.D. Kyoto Univ
2001  JSPS Research Fellow    
2002  JSPS Postdoctoral Research Fellow    
2003  RIKEN Special Postdoctoral Researcher    
2005  PRESTO Researcher of JST    
2008  Junior Associate Professor, Nagoya University      
2011  Associate Professor, Nagoya University    
2012  Professor, Institute for Molecular Science    
         Professor, The Graduate University for Advanced Studies   
2013  Director, Research Center of Integrative Molecular Systems   

Awards

2016  JSPS prize
2008  The Young Scientists' Prize (The Commendation for Science and Technology by
          the Minister of Education, Culture, Sports, Science and Technology, Japan)  
2007  Young Scientist Prize (from the Biophysical Society of Japan)     
2006  SAS Young Scientist Prize (from IUCr Commission on Small-angle
          Scattering)     
2002  The Protein Society Annual Poster Board Award     

2022  Nagase Foundation Award
 

Main research themes

Biological Rhythm & Dynamics, through Chemistry
kewords Circadian Clock, Cyanobacteria, Temperature Compensation
PDF Annual Review : PDF

Selected Publications

  1. S. Akiyama, “Structural and dynamic aspects of protein clocks: How can they be so slow and stable?” CMLS 69, 2147-2160 (2012).
  2. Y. Furuike et al., “Regulation Mechanisms of the Dual ATPase in KaiC” PNAS 119, e2119627119 (2022).
  3. Y. Furuike et al., “Elucidation of Master Allostery Essential for Circadian Clock Oscillation in Cyanobacteria” Sci. Adv. 8, eabm8990 (2022).
  4. J. Abe et al., “Atomic-scale Origins of Slowness in the Cyanobacterial Circadian Clock” Science 349, 312-316 (2015).
  5. Y. Furuike et al., “Cross-scale Analysis of Temperature Compensation in the Cyanobacterial Circadian Clock System” Commun. Phys. 5, 75 (2022).
  6. Furuike et al., "Regulation Mechanisms of the Dual ATPase in KaiC" PNAS 119, e2119627119 (2022).
  7. Mukaiyama et al., "Highly sensitive tryptophan fluorescence probe for detecting rhythmic conformational changes of KaiC in the cyanobacterial circadian clock system" Biochem. J. 479, 1505-1515 (2022).