The 777th IMS Colloquium

Seminar & Events Detail

Lecture Title	"Structural and Functional Properties of Nitric Oxide Synthase."
Date	Tuesday 18 October 2005 16:00
Place	Seminar room, 9th floor, Yamate No.3 Bldg.
Summary	Nitric oxide synthases (NOSs) are heme proteins that catalyze the formation of nitric oxide (NO) from L-arginine and oxygen in a sequential two-step process. Studies of the ligand-protein interactions in NOS will be discussed. Focus will be placed on the interactions of NO with the enzyme as it has been shown that this catalytic product auto-inhibits the enzyme. Spectroscopic studies will be presented that reveal a significant heme distortion in the enzyme and regulation of the monomer/dimer equilibrium by NO and the tetrahydrobiopterin cofactor. (The lecture will be presented in English.)

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