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Biomolecular sensing seminar

Lecture Title "ATP-dependent gating modulation of the Mg2+ channel MgtE for Mg2+ homeostasis"
Date Tuesday 28 March 2017 16:00 to 17:30
Lecturer Motoyuki Hattori (School of Life Sciences, Fudan University, Shanghai, China)

IMS Research Building 201


The Mg2+ ion is an essential element for numerous physiological processes, and Mg2+ homeostasis is a crucial mechanism for sustaining life. MgtE is a Mg2+ selective channel  widely distributed in all domains of life, and is involved in the maintenance of intracellular Mg2+ homeostasis. Previously reported crystal structures and electrophysiological analyses suggested the intracellular Mg2+-dependent gating mechanism of MgtE. However, in the previously reports, the threshold of intracellular Mg2+ for the channel inactivation was between 5-10 mM, which is much higher than the physiological intracellular Mg2+ concentration. Therefore, this discrepancy implied the existence of additional regulatory factors for the Mg2+-dependent gating of MgtE under physiological conditions.

Here, I will show that ATP binds to the cytosolic domain of MgtE and that a combination of biochemical, electrophysiological, genetics and structural analyses shows that ATP is a regulatory factor of MgtE that switches the channel gating mode for Mg2+ homeostasis.

 I will also briefly introduce the present situation of science in China.

* lecture in Japanese


Yuji Furutani