Seminar & Event Detail
Biomolecular sensing seminar
|Lecture Title||"ATP-dependent gating modulation of the Mg2+ channel MgtE for Mg2+ homeostasis"|
|Date||2017/03/28 (Tue) 16:00 ~ 17:30|
|Lecturer||Motoyuki Hattori (School of Life Sciences, Fudan University, Shanghai, China)|
IMS Research Building 201
The Mg2+ ion is an essential element for numerous physiological processes, and Mg2+ homeostasis is a crucial mechanism for sustaining life. MgtE is a Mg2+ selective channel widely distributed in all domains of life, and is involved in the maintenance of intracellular Mg2+ homeostasis. Previously reported crystal structures and electrophysiological analyses suggested the intracellular Mg2+-dependent gating mechanism of MgtE. However, in the previously reports, the threshold of intracellular Mg2+ for the channel inactivation was between 5-10 mM, which is much higher than the physiological intracellular Mg2+ concentration. Therefore, this discrepancy implied the existence of additional regulatory factors for the Mg2+-dependent gating of MgtE under physiological conditions.