Research
Seminar & Events
Lecture Title | "ATP-dependent gating modulation of the Mg2+ channel MgtE for Mg2+ homeostasis" |
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Date | Tuesday 28 March 2017 16:00 to 17:30 |
Lecturer | Motoyuki Hattori (School of Life Sciences, Fudan University, Shanghai, China) |
Place | IMS Research Building 201 |
Summary |
The Mg2+ ion is an essential element for numerous physiological processes, and Mg2+ homeostasis is a crucial mechanism for sustaining life. MgtE is a Mg2+ selective channel widely distributed in all domains of life, and is involved in the maintenance of intracellular Mg2+ homeostasis. Previously reported crystal structures and electrophysiological analyses suggested the intracellular Mg2+-dependent gating mechanism of MgtE. However, in the previously reports, the threshold of intracellular Mg2+ for the channel inactivation was between 5-10 mM, which is much higher than the physiological intracellular Mg2+ concentration. Therefore, this discrepancy implied the existence of additional regulatory factors for the Mg2+-dependent gating of MgtE under physiological conditions. |
Contact | Yuji Furutani |