Research
Seminar & Events
Lecture Title | "The Grateful Infrared – Novel IR Techniques to Probe the Functional Changes of Membrane Proteins" |
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Date | Tuesday 23 January 2018 16:00 |
Lecturer | Prof. Dr. Joachim Heberle (Freie Universitat Berlin, Dept. of Physics, Exp. Molecular Biophysics) |
Place | IMS Research Building, Seminar Room 201 |
Summary |
The catalytic activity of proteins is a function of structural changes. Very often these are as minute as protonation changes, hydrogen bonding changes and amino acid side chain reorientations. To resolve these, a methodology is afforded that not only provides the molecular sensitivity but allows to trace the sequence of these hierarchical reactions at the same time. I will showcase results from time-resolved IR spectroscopy using quantum cascade lasers [1,2] which was applied to channelrhodopsin [3], which represents the first light-activated ion channel to found the basis of the new and exciting field of optogenetics. A new ultrarapid-scanning FTIR spectrometer will also be introduced [4]. Finally, I shall provide an outlook towards novel experimental approaches like THz pump / IR probe spectroscopy or near-field IR nanoscopy (see figure below) that are currently developed in my lab [5]. We believe that some of these approaches have the potential to provide new science.
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Other |
Contact: Yuji Furutani (Department of Life and Coordination-Complex Molecular Science) |