The 6th Okazaki Molecular Engine Seminar

Seminar & Events Detail

Lecture Title	"Kinesin-14s: Moving into a New Paradigm"
Date	Monday 6 January 2020 16:00 to 17:00
Lecturer	Dr. Weihong Qiu (Assoc. Prof., Department of Physics, Oregon State University, USA)
Place	Common Seminar Room, 2nd floor, Yamate 3rd bldg.
Summary	Kinesin-14s are microtubule-based motor proteins that play important roles in cell division. They were originally thought to be minus-end-directed nonprocessive motors that exhibit directional preference toward the microtubule minus ends in multi-motor ensembles but are unable to generate processive (continuous) motility on single microtubules as individual motors. We and others have recently discovered several “unconventional” kinesin-14 motors that all contain the ability to generate processive motility as individual motors on single microtubules. In this talk, I will present a series of unexpected yet exciting findings from my lab that have markedly expanded current view of the design and operation principles of kinesin-14 motors. References: Gicking A.M. et al., Biophys. J. 116: 1270-1281 (2019) Wang P. et al., Cur. Biol. 28: 2302-2308 (2018) Tseng K.F. et al., Nat. Commun. 9: 1067 (2018) Popchock A.R. et al., Nat. Commun. 8: 13999 (2017) ------------------------------------------------ For more information here.
Contact	Ryota IINO (#5230)

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