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The 967th IMS colloquium

Lecture Title "Insights into Transmembrane Ion Transport by Ionophores; Selectivity and Mechanisms"
Date Monday 15 May 2023 16:00 to 17:30
Lecturer Prof. James M. Lisy (University of Illinois Urbana-Champaign)
Place

IMS Research Building Room 201
Summary

There are two primary methods for ions to traverse cell membranes: ion channels and ionophores. A delicate balance of non-covalent interactions enables these charged species to move from the hydrophilic regions (intra- and extra-cellular) through the hydrophobic cell membrane. Using infrared laser spectroscopy combined with mass spectrometric detection, aided by computational structural analysis, I will present results on three different ionophores: the synthetic 18-Crown-6 cyclic ether, and two naturally occurring ionophores valinomycin and beauvericin. The first two preferentially bind K+ over the other alkali metal ions, while beauvericin shows a preference for Na+. 

 

Relevant publications:

  • Infrared Spectroscopy of Ionophore-Model Systems: Hydrated Alkali Metal Ion 18-Crown-6 Ether Complexes, Jason D. Rodriguez, Timothy D. Vaden and James M. Lisy, J. Am. Chem. Soc., 131, 17277-85 (2009).
  • Probing Ionophore Selectivity in Argon-Tagged Hydrated Alkali Metal Ion–Crown Ether Systems, Jason D. Rodriguez and James M. Lisy, J. Am. Chem. Soc., 133 11136-46 (2011)
  • Rethinking Ion Transport by Ionophores: Experimental and Computational Investigation of Single Water Hydration in Valinomycin-K+ Complexes, Eiko Sato, Keisuke Hirata, James M. Lisy, Shun-ichi Ishiuchi, and Maasaki Fujii, J. Phys. Chem. Letts. 12, 1754-8 (2021).
  • Na+ Selective Binding by Beauvericin and Its Mechanism Studied by Mass-Coupled Cold Ion Trap Infrared Spectroscopy, Kien Vo, Keisuke Hirata, James M. Lisy, Shun-ichi Ishiuchi, Masaaki Fujii, J. Phys. Chem. Letts., 13, 11330-34 (2022).
Contact

Hikaru Kuramochi & Yasutomo Segawa （IMS colloquium FY2023 committee）
Awards & Honors International collaboration

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