研究・研究者
研究会・セミナー
| 演 題 | 「Structural and Functional Properties of Nitric Oxide Synthase.」 |
|---|---|
| 日 時 | 2005年10月18日(火) 16:00 |
| 場 所 | 山手３号館９階セミナー室（場所がいつもと違います。ご注意ください） |
| 概 要 |
Nitric oxide synthases (NOSs) are heme proteins that catalyze the formation of nitric oxide (NO) from L-arginine and oxygen in a sequential two-step process. Studies of the ligand-protein interactions in NOS will be discussed. Focus will be placed on the interactions of NO with the enzyme as it has been shown that this catalytic product auto-inhibits the enzyme. Spectroscopic studies will be presented that reveal a significant heme distortion in the enzyme and regulation of the monomer/dimer equilibrium by NO and the tetrahydrobiopterin cofactor. |
