研究・研究者
研究会・セミナー
| 演 題 | 「Preparation and Preliminary Application of Multistimuli- responsive Hybrid Polymer Microspheres」 |
|---|---|
| 日 時 | 2007年08月10日(金) 15:30 |
| 講演者 | Prof. Changchun Wang (Fudan University) |
| 場 所 | 山手4号館3階 ナノセンター会議室 |
| 概 要 |
中国 Fudan大学のChangchun Wang教授を迎えて、講演会を開催いたします。 We present a new approach for the fabrication of stimuli- responsive microspheres with useful properties. The stimuli- responsive microspheres have a well-defined core-shell structure and multistimuli-responsive properties. For these microspheres, the core is made of FITC-labeled magnetic composite spheres and the shell is made of crosslinked poly(N-isopropylacrylamide) (PNIPAM). FITC, a popular fluorescent probe, has been widely used in various fields such as cell labeling and DNA-sequence detection. PNIPAM is a well- known thermoresponsive polymer with a lower critical solution temperature (LCST) of 32.8 °C and has been extensively studied in many fields including drug delivery, purification of proteins, and gene expression. To further investigate the possible applications of the prepared multistimuli-responsive microspheres, we studied their drug-loading efficiency and in vitro drug-release behavior by using doxorubicin (DOX, a hydrophilic antitumor drug) as the model drug. In addition, by using these microspheres as tracers, we studied the magnetic-targeting effect of the microspheres by comparing the in vivo distribution of the microspheres in the presence and absence of an external magnetic field. The results suggest that such multistimuli-responsive microspheres, due to their photophysical and photochemical properties and sensitivity to both external magnetic field and environmental temperature, hold great potential for the design of controlled drugdelivery methods, in which microspheres loaded with a drug could be guided to the tissue of interest by using a magnetic field, followed by release of the drug by changing the local temperature. As a result of the enrichment of fluorescence molecules, these microspheres could serve as efficient tracers of drug carriers to study the magnetic-targeting effect of magnetic microspheres. Furthermore, some multistimuli-resposive microspheres with QDs also have been prepared. |
| お問合せ先 | 江東林（物質分子科学研究領域） |
