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第837回分子研コロキウム

演 題 「Water in Chemistry and Biology : Unique Features of H2O」
日 時 2012年06月15日(金) 16:00
講演者 Biman Bagchi (Indian Institute of Science)
場 所

分子科学研究所 研究棟 201セミナー室

概 要

Water brings its remarkable thermodynamic and dynamic anomalies in the liquid state to the biological world where water molecules face a multitude of additional interactions that frustrate water’s hydrogen bond network. Yet the water molecules participate and control enormous number of biological processes in manners which are yet to be understood at a molecular level. We discuss structure, dynamics and properties of water in proteins and DNA, along with those in reverse micelles. We discuss the roles of water in enzyme kinetics, in drug-DNA intercalation and in kinetic proof reading (the theory of lack of errors in biosynthesis).[1-4] We also discuss how water may play an important role in the natural selection of biomolecules.


1) B. Bagchi, Chem. Phys. Lett. (Frontier Article) 529, 1-9 (2012);  B. Bagchi. Chem. Rev., 105 , 3196 (2005); B. Bagchi and B. Jana, Chem. Soc. Rev. [Tutorial Review] 39 (2010)  1936.

2) (a)  D. Zhong, S.K. Pal, and A.H. Zewail. Chem. Phys. Lett., 503 (2011), p. 1;  (b) S. K. Pal and A. H. Zewail, Chemical Reviews 104 (2004) p. 2099;  (c) S.K. Pal, J. Peon, B Bagchi, A.H.  Zewail, J. Phys. Chem, 106  (2002) 12376 [Protein hydration dynamics]

3) S. Pal, P. K. Maiti, S. -T. Lin, J. T. Hynes, and B. Bagchi, J. Phys. Chem. B 110, 19611 (2006). [DNA hydration dynamics]

4) S. Roy and B Bagchi, J. Phys. Chem. (2012)

お問合せ先

斉藤真司(理論・計算分子科学研究領域)
櫻井英博(分子スケールナノサイエンスセンター)(2012年度コロキウム委員)