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演 題 「Shedding light on Nature's molecular eyes: photoactivation mechanisms of novel blue and red-light photoreceptors.」
日 時 2012年11月20日(火) 16:00 より 18:00 まで
講演者 Dr. John T.M. Kennis
場 所

分子科学研究所 研究棟2階 201セミナー室

概 要

Photoreceptor proteins, Nature's 'molecular eyes' are exceptionally interesting objects of study, not only in relation to their biological function but also because they can be triggered by a short flash of light, allowing the study of functional protein dynamics over a wide span of timescales. In this lecture, I will give an overview of the recent work in my laboratory to discover the molecular basis of the light-activated function of photoreceptor proteins. In particular, ultrafast time-resolved spectroscopy has revealed how carefully timed electron, proton and hydrogen transfer processes constitute key events in the photoactivation of two recently discovered photoreceptors: BLUF domains and bacteriophytochrome.

Key publications
T. Mathes, J. Zhu, I.H.M. van Stokkum, M.L. Groot, P. Hegemann, J.T.M. Kennis Hydrogen bond switching among flavin and amino acids determines the nature of proton-coupled electron transfer in BLUF photoreceptors.
J. Phys. Chem. Lett. (2012) 3, 203-208.

M. Kloz, S. Pillai, G. Kodis, D. Gust, T.A. Moore, A. L. Moore, R. van Grondelle, J.T.M. Kennis Carotenoid photoprotection in artificial photosynthetic antennas.
J Am Chem Soc 133 (2011) 7007-7015.

M. Kloz, R. van Grondelle, J.T.M. Kennis Wavelength-modulated femtosecond stimulated Raman spectroscopy - approach towards automatic data processing.
Phys. Chem. Chem. Phys. 13 (2011) 18123-18133.

K.C. Toh, E.A. Stojkovic, I.H.M. van Stokkum, K. Moffat, J.T.M. Kennis Proton transfer and hydrogen bond interactions determine fluorescence quantum yield and photochemical efficiency of bacteriophytochrome Proc. Natl. Acad. Sci. (USA) 107, (2010) 9170 - 9175.

C. Bonetti, T. Mathes, I.H.M. van Stokkum, K.M. Mullen, M.L. Groot, R. van Grondelle, P. Hegemann, J.T.M. Kennis Hydrogen bond switching among flavin and amino acid side chains in the BLUF photoreceptor observed by ultrafast infrared spectroscopy.
Biophys. J. 95, 2008, pp. 4790 - 4802.

Note
He was awarded the 2012 Morino Lectureship for the Promotion of Molecular Sciences.

その他

Associate Professor at VU University Amsterdam

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