研究・研究者
研究会・セミナー
| 演 題 | 「Mechanistic studies of the Ras-superfamily by FTIR spectroscopy」 |
|---|---|
| 日 時 | 2013年08月30日(金) 16:00 より 18:00 まで |
| 講演者 | PD Dr. Carsten Kötting Permanent Position "PD", Department of Biology and Biotechnology, Ruhr-University Bochum |
| 場 所 | Yamate Building 3, 2nd floor, Seminar Room |
| 概 要 |
The Ras protein is mutated in 30% of human tumors. Ras acts as a switch, transmitting a growth signal in an active GTP-bound form and turning the signal off in an inactive GDP-bound form. The switch-off is accomplished by GTP hydrolysis, which is catalyzed by Ras and can be further accelerated by GTPase activating proteins (GAPs). Mutations which inhibit hydrolysis cause severe diseases including cancer. We investigated the reaction of the Ras·GAP protein-protein complex by time-resolved FTIR spectroscopy by means of caged-GTP.1 This method was also applied to other GTPases.2 |
| お問合せ先 | Yuji Furutani |
