研究・研究者
研究会・セミナー
| 演 題 | 「Inorganic Control of Cellular Decisions: Connecting Transition Metal Fluxes, Receptors and Sensors at the Atomic Level」 |
|---|---|
| 日 時 | 2014年03月25日(火) 16:00 より 17:30 まで |
| 講演者 | Prof. Thomas O'Halloran (Northwestern Univ., Director of the Chemistry of Life Processes Institute) 【分子科学研究所 外国人運営顧問】 |
| 場 所 | 分子科学研究所 研究棟2階 201号室 |
| 概 要 | In one area we are focusing on chemistry, structure, and function of the metalloregulatory proteins. These small proteins act as metal receptors that regulate gene expression. We have proposed that another class of metalloproteins acts as chaperones for metal ions within the cell. Such proteins may have reasonable thermodynamic binding constants for specific metal ions, but can undergo rapid ligand exchange reactions in which the metal ion is passed to the proper biological partner. Characterization of these proteins will reveal fundamental molecular aspects of heavy-metal homeostasis and may provide insight into fatal metal-based disorders, such as Menkes’ syndrome and Wilson’s disease.
As we probe the structures and the substitution mechanisms of the metal centers in these proteins, we are learning how many well-established inorganic principles apply in the highly compartmentalized chemistry of the cell. These new rules in turn are used to design inorganic medicines for the control of human disease.
Prof. Thomas O'Halloran
|
| お問合せ先 |
青野重利（統合バイオ） |
