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演　題	「Protonation and Conformation Dynamics in Channelrhodopsin-2 and their Relevance in Cation Conductance」
日　時	2014年10月01日(水) 11:00 より 12:30 まで
講演者	Dr. Victor A. Lorenz-Fonfria （Institute of Experimental Molecular Biophysics, Department of Physcis, Freie Universität, Germany）
場　所	研究棟301号室
概　要	Channelrhodopsins (ChRs) are sensory microbial rhodopsins that have become renowned for being the first and so far the only light-gated ion channels known in nature. ChR2 from the alga Chlamydomonas reinhardtii has been used for nearly a decade to depolarize the cell membrane of excitable cells by light, making it a prominent tool in the field optogenetics. The functional mechanism of ChRs remains relatively poorly understood in molecular terms. In our group we have used time-resolved optical and vibrational spectroscopies combined with site-directed mutagenesis to gain information about the molecular mechanism that links retinal isomerization to the opening of the ion channel. Here, I will provide an overview on proton transfer reactions occurring in the photocycle of ChR2, and the role they might play in the closure of the conductive state of the channel. I will also present new results on the role and nature of conformational changes accompanying the formation of the conductive state of the channel.
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