生体分子情報セミナー

セミナー・イベント詳細

演　題	「ATP-dependent gating modulation of the Mg²⁺ channel MgtE for Mg²⁺ homeostasis」
日　時	2017年03月28日(火) 16:00 より 17:30 まで
講演者	服部素之教授（復旦大学・生命科学学院）
場　所	分子科学研究所　研究棟201号室
概　要	The Mg²⁺ ion is an essential element for numerous physiological processes, and Mg²⁺ homeostasis is a crucial mechanism for sustaining life. MgtE is a Mg²⁺ selective channel widely distributed in all domains of life, and is involved in the maintenance of intracellular Mg²⁺ homeostasis. Previously reported crystal structures and electrophysiological analyses suggested the intracellular Mg²⁺-dependent gating mechanism of MgtE. However, in the previously reports, the threshold of intracellular Mg²⁺ for the channel inactivation was between 5-10 mM, which is much higher than the physiological intracellular Mg²⁺ concentration. Therefore, this discrepancy implied the existence of additional regulatory factors for the Mg²⁺-dependent gating of MgtE under physiological conditions. Here, I will show that ATP binds to the cytosolic domain of MgtE and that a combination of biochemical, electrophysiological, genetics and structural analyses shows that ATP is a regulatory factor of MgtE that switches the channel gating mode for Mg²⁺ homeostasis. I will also briefly introduce the present situation of science in China. ＊日本語での講演となります。
お問合せ先	古谷祐詞

受賞一覧国際連携