研究・研究者
研究会・セミナー
演 題 | 「The Grateful Infrared – Novel IR Techniques to Probe the Functional Changes of Membrane Proteins」 |
---|---|
日 時 | 2018年01月23日(火) 16:00 |
講演者 | Prof. Dr. Joachim Heberle (Freie Universitat Berlin, Dept. of Physics, Exp. Molecular Biophysics) |
場 所 | 分子科学研究所 研究棟201号室 |
概 要 |
The catalytic activity of proteins is a function of structural changes. Very often these are as minute as protonation changes, hydrogen bonding changes and amino acid side chain reorientations. To resolve these, a methodology is afforded that not only provides the molecular sensitivity but allows to trace the sequence of these hierarchical reactions at the same time. I will showcase results from time-resolved IR spectroscopy using quantum cascade lasers [1,2] which was applied to channelrhodopsin [3], which represents the first light-activated ion channel to found the basis of the new and exciting field of optogenetics. A new ultrarapid-scanning FTIR spectrometer will also be introduced [4]. Finally, I shall provide an outlook towards novel experimental approaches like THz pump / IR probe spectroscopy or near-field IR nanoscopy (see figure below) that are currently developed in my lab [5]. We believe that some of these approaches have the potential to provide new science.
|
その他 |
対応者:古谷祐詞(生命・錯体分子科学研究領域) |