研究・研究者
研究会・セミナー
| 演 題 | 「Theoretical Investigations of Biological Nano-Machines」 |
|---|---|
| 日 時 | 2018年05月18日(金) 15:00 |
| 講演者 | Prof. Alexander S. Mikhailov （Fritz Haber Institute of the Max Planck Society/Nano Life Science Institute, Kanazawa University WPI） |
| 場 所 | 分子科学研究所 研究棟201号室 |
| 概 要 |
Protein machines, acting as molecular motors or ion pumps and manipulating other biomolecules, such as DNA, play a fundamental role in living cells. Similar to the machines invented by humans to deal efficiently with the macroscopic world, they contain highly coordinated moving parts1. Functional conformational motions in these machines are faithfully repeated in each next operation cycle, despite the fact that such devices are based on soft matter and there are strong fluctuations at microscales. Proceeding from our theoretical studies, I will argue that biological nano-machines correspond to a special kind of proteins selected by evolution2-4; I will also discuss how artificial molecular structures with such properties can be in principle designed2,6. In our investigations, we use coarse-grained elastic-network models of proteins, whose efficiency is validated by additional full MD simulations6 and by testing their predictions against a set of NMR data for many proteins7. |
| その他 | 所内対応者：藤 貴夫、椴山 儀恵（2018年度コロキウム委員） |
