研究・研究者
研究会・セミナー
| 演 題 | 「Very Strong and Confined Acids Enable a General Approach to Asymmetric Lewis Acid Catalysis」 |
|---|---|
| 日 時 | 2018年11月08日(木) 16:00 |
| 講演者 | Prof. Benjamin List （Max-Planck-Institut für Kohlenforschung） |
| 場 所 | 分子科学研究所 研究棟201号室 |
| 概 要 |
As a fundamental activation mode, Lewis acid catalysis enables key reactions in chemical synthesis, such as the Diels–Alder and Friedel–Crafts reactions, and various aldol, Mannich, and Michael reactions. Consequently, substantial efforts have been directed towards the development of enantiopure Lewis acids, which have enabled important asymmetric variations of such reactions. Despite the plethora of elegant catalysts and methodologies developed in this context, a key limitation of enantioselective Lewis acid catalysis is the frequent need for relatively high catalyst loadings, which result from issues such as insufficient Lewis acidity, product inhibition, hydrolytic instability, and background catalysis. |
| その他 |
所内対応者：魚住 泰広（生命・錯体分子科学研究領域） |
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