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第6回岡崎発動分子科学セミナー

演 題 「Kinesin-14s: Moving into a New Paradigm」
日 時 2020年01月06日(月) 16:00 より 17:00 まで
講演者 Dr. Weihong Qiu(Assoc. Prof., Department of Physics, Oregon State University, USA)
場 所

山手3号館2階共通セミナー室

概 要

Kinesin-14s are microtubule-based motor proteins that play important roles in cell division. They were originally thought to be minus-end-directed nonprocessive motors that exhibit directional preference toward the microtubule minus ends in multi-motor ensembles but are unable to generate processive (continuous) motility on single microtubules as individual motors. We and others have recently discovered several “unconventional” kinesin-14 motors that all contain the ability to generate processive motility as individual motors on single microtubules. In this talk, I will present a series of unexpected yet exciting findings from my lab that have markedly expanded current view of the design and operation principles of kinesin-14 motors.
 

References:
Gicking A.M. et al., Biophys. J. 116: 1270-1281 (2019)
Wang P. et al., Cur. Biol. 28: 2302-2308 (2018)
Tseng K.F. et al., Nat. Commun. 9: 1067 (2018)
Popchock A.R. et al., Nat. Commun. 8: 13999 (2017)

◆詳細はこちら(PDF)をご覧ください。

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