研究・研究者
研究会・セミナー
| 演 題 | 「Development of artificial metalloenzymes for novel in vitro application」 |
|---|---|
| 日 時 | 2022年11月21日(月) 15:00 より 16:00 まで |
| 講演者 | Prof. Shyamalava Mazumdar (Department of Chemical Sciences, Tata Institute of Fundamental Research, India) |
| 場 所 | 分子科学研究所 研究棟201 ＆ Zoom online |
| 概 要 | Biocatalytic processes by far provide the best eco-friendly ways to synthesize fine chemicals. Metalloenzymes are known to catalyze chemical reactions with exceptionally high regio and enantioselectivity and with faster reaction kinetics. Metalloenzymes become more desirable than conventional chemical catalysts for the chemical transformation of the substrate having multiple functional groups. Due to their high selectivity, metalloenzymes perform chemical modification at a particular site without hampering other more reactive functional groups on the substrates. One limitation of the metalloenzymes is that they show a narrow substrate range and often do not catalyze the transformation of non-native substrates. Recent advancements in the field, such as ‘directed evolution’ and ‘rational enzyme design’, have substantially expanded the substrate horizon of the metalloenzymes. Furthermore, the catalytic activity of the metalloenzymes is limited to the inherent activity of their natural metal co-factor. To expand the reaction scope of the metalloenzymes, researchers have replaced natural co-factor with abiotic metal co-factor. Despite all the remarkable properties, metalloenzymes have not substantially contributed at an industrial scale. The talk would discuss various aspects of the metalloenzymes, such as their structure, functions, the role of the metal center in the catalytic activity, current limitations, and challenges for industrial-scale applications and highlight our recent efforts in this challenging area.
Registration
IMS Seminar by Prof. S. Mazumdar
ミーティングID: 894 5838 5155 |
| お問合せ先 |
青野重利 (aono_at_ims.ac.jp) |
