研究・研究者
研究会・セミナー
演 題 | 「Insights into Transmembrane Ion Transport by Ionophores; Selectivity and Mechanisms」 |
---|---|
日 時 | 2023年05月15日(月) 16:00 より 17:30 まで |
講演者 | Prof. James M. Lisy (University of Illinois Urbana-Champaign) |
場 所 | 分子科学研究所 研究棟201 |
概 要 | There are two primary methods for ions to traverse cell membranes: ion channels and ionophores. A delicate balance of non-covalent interactions enables these charged species to move from the hydrophilic regions (intra- and extra-cellular) through the hydrophobic cell membrane. Using infrared laser spectroscopy combined with mass spectrometric detection, aided by computational structural analysis, I will present results on three different ionophores: the synthetic 18-Crown-6 cyclic ether, and two naturally occurring ionophores valinomycin and beauvericin. The first two preferentially bind K+ over the other alkali metal ions, while beauvericin shows a preference for Na+.
Relevant publications:
|
お問合せ先 | 倉持 光、瀬川 泰知(2023年度コロキウム委員) |