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第967回分子研コロキウム

演 題 「Insights into Transmembrane Ion Transport by Ionophores; Selectivity and Mechanisms」
日 時 2023年05月15日(月) 16:00 より 17:30 まで
講演者 Prof. James M. Lisy (University of Illinois Urbana-Champaign)
場 所

分子科学研究所 研究棟201

概 要

There are two primary methods for ions to traverse cell membranes: ion channels and ionophores. A delicate balance of non-covalent interactions enables these charged species to move from the hydrophilic regions (intra- and extra-cellular) through the hydrophobic cell membrane. Using infrared laser spectroscopy combined with mass spectrometric detection, aided by computational structural analysis, I will present results on three different ionophores: the synthetic 18-Crown-6 cyclic ether, and two naturally occurring ionophores valinomycin and beauvericin. The first two preferentially bind K+ over the other alkali metal ions, while beauvericin shows a preference for Na+

 

Relevant publications:

  • Infrared Spectroscopy of Ionophore-Model Systems: Hydrated Alkali Metal Ion 18-Crown-6 Ether Complexes, Jason D. Rodriguez, Timothy D. Vaden and James M. Lisy, J. Am. Chem. Soc., 131, 17277-85 (2009).
  • Probing Ionophore Selectivity in Argon-Tagged Hydrated Alkali Metal Ion–Crown Ether Systems, Jason D. Rodriguez and James M. Lisy, J. Am. Chem. Soc., 133 11136-46 (2011)
  • Rethinking Ion Transport by Ionophores: Experimental and Computational Investigation of Single Water Hydration in Valinomycin-K+ Complexes, Eiko Sato, Keisuke Hirata, James M. Lisy, Shun-ichi Ishiuchi, and Maasaki Fujii, J. Phys. Chem. Letts. 12, 1754-8 (2021).
  • Na+ Selective Binding by Beauvericin and Its Mechanism Studied by Mass-Coupled Cold Ion Trap Infrared Spectroscopy, Kien Vo, Keisuke Hirata, James M. Lisy, Shun-ichi Ishiuchi, Masaaki Fujii, J. Phys. Chem. Letts., 13, 11330-34 (2022).
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倉持 光、瀬川 泰知(2023年度コロキウム委員)